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Five types of people who should be careful taking paracetamol

Home> Life

Published 17:05 5 Dec 2025 GMT

Five types of people who should be careful taking paracetamol

Paracetamol is generally safe for people to consume - unless you're in one of these five groups

Rhianna Benson

Rhianna Benson

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Featured Image Credit: Getty Stock Images

Topics: Health, Life, Real Life, True Life, NHS, Advice

Rhianna Benson
Rhianna Benson

Rhianna is an Entertainment Journalist at LADbible Group, working across LADbible, UNILAD and Tyla. She has a Masters in News Journalism from the University of Salford and a Masters in Ancient History from the University of Edinburgh. She previously worked as a Celebrity Reporter for OK! and New Magazines, and as a TV Writer for Reach PLC.

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There's almost no pain that paracetamol can't tend to.

Toothache? Check. Sore throat? You betcha. Menstrual craps? It's got you covered. I'd even go as far as to suggest popping a pill or two if you ever finding yourself having been run over, given their ability to numb even the severest of aches - on doctors orders, of course.

And with the harsh winter winds now having arrived in full force, these trusted tablets are flying off the shelves in a bid to ward off colds and flus.

"Paracetamol is a common painkiller used to treat aches and pain," the NHS explains. "It can also be used to reduce a high temperature. It's available to buy from a pharmacy or shop, but you may be able to get 1g tablets on prescription if you have long-term pain.

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These pills are generally recommended for colds and flus (Getty Stock Images)
These pills are generally recommended for colds and flus (Getty Stock Images)

"It comes as tablets, capsules, syrup, powder that you mix with water, or suppositories. The 1g tablets are only available if prescribed by a doctor."

The effectiveness of these powerful, agony-suppressing pills is why they're so popular in almost all countries around the world - this, and the fact they're cheap, widely available and generally safe for people to consume.

Notice how we say 'generally', here, however? Well, that's because, according to some leading medics, there are certain groups of people who mightn't respond too well to paracetamol, or similar pain-killing drugs - five groups, in fact.

1) People who take certain medications

Though paracetamol is usually safe for consumption alongside prescription meds and antibiotics, in some cases, this isn't advised.

This is especially the case for individuals taking warfarin to keep blood clots at bay, and those on medication for either epilepsy or tuberculosis.

People taking other types of medication must be wary (Getty Stock Images)
People taking other types of medication must be wary (Getty Stock Images)

In each of these cases, it's advisable to chat to a doctor before popping a trustee painkiller.

With regards to other painkillers, the NHS says: "It's safe to take paracetamol with other types of painkiller that do not contain paracetamol, such as ibuprofen, aspirin or codeine."

To take two different medications containing paracetamol heightens the risk of an overdose.

2) People with liver or kidney problems

According to the American College of Gastroenterology, sufferers of liver or kidney issues approach paracetamol with caution, given that processes prompted by these two organs are responsible for eliminating it from the body.

As such, if either struggle, it increases the risk of toxic build up, which could result in either severe liver damage or acute kidney failure, even if consumed at normal doses.

People with liver and kidney issues should approach with caution (Getty Stock Images)
People with liver and kidney issues should approach with caution (Getty Stock Images)

3) Big drinkers

People who regularly consume more than the maximum amount of alcohol recommended per week - which is 14 units in the UK - run the risk of severe liver damage, liver failure, and even death.

This is because, as mentioned above, both booze and painkillers are processed by the liver, and their combined effect puts this vital organ under tremendous amounts of stress.

4) People who weigh less than 50kg

Individuals weighing fewer than eight stone run an increased risk of enduring toxicity, being that standard adult dose (up to 4g per day) might be too high for them.

This isn't to say that they can't rely on these painkillers at all - just that their dosage may need to be adjusted by a healthcare professional.

Individuals that weigh less than 50kg might need lower doses (Getty Stock Images)
Individuals that weigh less than 50kg might need lower doses (Getty Stock Images)

5) People who've had allergic reactions to paracetamol, or similar medicines

It might sound obvious, but we're going to say it anyway.

If you're someone what has suffered an allergic reaction to paracetamol - or similar over-the-counter painkiller/cold and flu meds - you must avoid it altogether going forwards.

This is because re-exposure can trigger another, potentially more severe, allergic reaction, including life-threatening anaphylaxis or serious skin reactions.

The body's immune system 'remembers' the substance and reacts more strongly upon subsequent exposure.

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