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Christina Applegate reveals 'f*****g s**t' symptom she’s been experiencing since MS diagnosis

Home> Entertainment> Celebrity

Published 16:19 10 Jun 2025 GMT+1

Christina Applegate reveals 'f*****g s**t' symptom she’s been experiencing since MS diagnosis

The Dead To Me actress received her chronic diagnosis in 2021

Rhianna Benson

Rhianna Benson

Featured Image Credit: Frazer Harrison/Getty Images/SiriusXM

Topics: Christina Applegate, Celebrity, US News, Health

Rhianna Benson
Rhianna Benson

Rhianna is an Entertainment Journalist at LADbible Group, working across LADbible, UNILAD and Tyla. She has a Masters in News Journalism from the University of Salford and a Masters in Ancient History from the University of Edinburgh. She previously worked as a Celebrity Reporter for OK! and New Magazines, and as a TV Writer for Reach PLC.

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@rhiannaBjourno

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Multiple sclerosis (MS) sufferer Christina Applegate has opened up on one of the most 'f*****g bizarre' symptoms of the condition.

The much-loved Dead to Me actress was diagnosed with MS back in 2021.

Since then, she has used her diagnosis as a means of dispelling taboos relating to the chronic condition, as well as raise awareness of both the most common and most obscure symptoms.

For those in need of a reminder, MS is a life-long ailment which sees both the brain and the spinal cord mistakenly attacked by the immune system, which fails to recognise it.

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According to the NHS: "This damages and scars the sheath, and potentially the underlying nerves, meaning that messages travelling along the nerves become slowed or disrupted."

Christina Applegate regularly discusses her experience with the condition (Frazer Harrison/Getty Images)
Christina Applegate regularly discusses her experience with the condition (Frazer Harrison/Getty Images)

The 53-year-old has long been an open book when it comes to her experience with MS, speaking about the highs and lows of the condition on her MeSsy podcast - which she presents with fellow sufferer Jamie-Lynn Sigler.

And this week, Applegate claimed she'd been surprised to find out how the lesions on her brain caused by the condition affect her mobility.

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Sigler began the discussion, emphasising how important to discuss every possibly side effect with medics.

"I think that the more we can understand what's happening to us, we also can give ourselves, like, a little more grace, a few more pats on the back, maybe? I don't know," she admitted

"I totally am right there with you," Applegate agreed. "When I hear this stuff, I'm like, 'Oh no, but I'm fine brain-wise'. But I have a disease of the brain."

She went on to reveal: "If I touch my forehead, my toes curl.

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The movie star described the sensation as 'f*****g bonkers' (VALERIE MACON/AFP via Getty Images)
The movie star described the sensation as 'f*****g bonkers' (VALERIE MACON/AFP via Getty Images)

"Has that ever happened to you? Well, no, because you don't have all the lesions on the brain."

The Anchorman actress then elaborated on the peculiar symptom, adding: "When I touch my forehead sometimes - like, right now - my toes are curling.

"Oh, you should see this f*****g s**t going on. My whole foot is rotating right now from just touching."

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Later on in the podcast, Applegate could be heard demonstrating her involuntary foot movement, with Sigler chiming in to say: "That's so weird. She's touching her forehead and her foot is moving."

"Yeah," the movie star went on. "It's f*****g bonkers."

Applegate also revealed that the odd sensational wasn't limited to her forehead and foot.

"If I touch, like, my hip, then my left leg will do weird s**t," she said.

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"It's all so connected with this disease. With the nerve situation."

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