• News
  • Life
  • TV & Film
  • Beauty
  • Style
  • Home
  • News
    • Celebrity
    • Entertainment
    • Politics
    • Royal Family
  • Life
    • Animals
    • Food & Drink
    • Women's Health
    • Mental Health
    • Sex & Relationships
    • Travel
    • Real Life
  • TV & Film
    • True Crime
    • Documentaries
    • Netflix
    • BBC
    • ITV
    • Tyla Recommends
  • Beauty
    • Hair
    • Make-up
    • Skincare
  • Style
    • Home
    • Fashion
    • Shopping
  • Advertise
  • Terms
  • Privacy & Cookies
  • LADbible Group
  • LADbible
  • UNILAD
  • SPORTbible
  • GAMINGbible
  • UNILAD Tech
  • FOODbible
  • License Our Content
  • About Us & Contact
  • Jobs
  • Latest
  • Topics A-Z
  • Authors
Facebook
Instagram
X
Threads
TikTok
Submit Your Content
Christina Applegate reveals 'f*****g s**t' symptom she’s been experiencing since MS diagnosis

Home> Entertainment> Celebrity

Published 16:19 10 Jun 2025 GMT+1

Christina Applegate reveals 'f*****g s**t' symptom she’s been experiencing since MS diagnosis

The Dead To Me actress received her chronic diagnosis in 2021

Rhianna Benson

Rhianna Benson

Multiple sclerosis (MS) sufferer Christina Applegate has opened up on one of the most 'f*****g bizarre' symptoms of the condition.

The much-loved Dead to Me actress was diagnosed with MS back in 2021.

Since then, she has used her diagnosis as a means of dispelling taboos relating to the chronic condition, as well as raise awareness of both the most common and most obscure symptoms.

Advert

For those in need of a reminder, MS is a life-long ailment which sees both the brain and the spinal cord mistakenly attacked by the immune system, which fails to recognise it.

According to the NHS: "This damages and scars the sheath, and potentially the underlying nerves, meaning that messages travelling along the nerves become slowed or disrupted."

Christina Applegate regularly discusses her experience with the condition (Frazer Harrison/Getty Images)
Christina Applegate regularly discusses her experience with the condition (Frazer Harrison/Getty Images)

The 53-year-old has long been an open book when it comes to her experience with MS, speaking about the highs and lows of the condition on her MeSsy podcast - which she presents with fellow sufferer Jamie-Lynn Sigler.

Advert

And this week, Applegate claimed she'd been surprised to find out how the lesions on her brain caused by the condition affect her mobility.

Sigler began the discussion, emphasising how important to discuss every possibly side effect with medics.

"I think that the more we can understand what's happening to us, we also can give ourselves, like, a little more grace, a few more pats on the back, maybe? I don't know," she admitted

"I totally am right there with you," Applegate agreed. "When I hear this stuff, I'm like, 'Oh no, but I'm fine brain-wise'. But I have a disease of the brain."

Advert

She went on to reveal: "If I touch my forehead, my toes curl.

The movie star described the sensation as 'f*****g bonkers' (VALERIE MACON/AFP via Getty Images)
The movie star described the sensation as 'f*****g bonkers' (VALERIE MACON/AFP via Getty Images)

"Has that ever happened to you? Well, no, because you don't have all the lesions on the brain."

The Anchorman actress then elaborated on the peculiar symptom, adding: "When I touch my forehead sometimes - like, right now - my toes are curling.

Advert

"Oh, you should see this f*****g s**t going on. My whole foot is rotating right now from just touching."

Later on in the podcast, Applegate could be heard demonstrating her involuntary foot movement, with Sigler chiming in to say: "That's so weird. She's touching her forehead and her foot is moving."

"Yeah," the movie star went on. "It's f*****g bonkers."

Applegate also revealed that the odd sensational wasn't limited to her forehead and foot.

Advert

"If I touch, like, my hip, then my left leg will do weird s**t," she said.

"It's all so connected with this disease. With the nerve situation."

Featured Image Credit: Frazer Harrison/Getty Images/SiriusXM

Topics: Christina Applegate, Celebrity, US News, Health

Rhianna Benson
Rhianna Benson

Rhianna is an Entertainment Journalist at LADbible Group, working across LADbible, UNILAD and Tyla. She has a Masters in News Journalism from the University of Salford and a Masters in Ancient History from the University of Edinburgh. She previously worked as a Celebrity Reporter for OK! and New Magazines, and as a TV Writer for Reach PLC.

X

@rhiannaBjourno

Advert

Advert

Advert

Choose your content:

a day ago
  • a day ago

    Hannah Montana star denies taking drugs on set as Miley Cyrus makes shocking confession

    The 32-year-old 'Flowers' singer made the bombshell confession on her mum and sister's Sorry We're Cyrus podcast

    Entertainment
  • a day ago

    Lilo and Stitch fans have 'goosebumps' after realising why original movie was forced to be drastically changed

    The Disney classic could have been a very different film without the changes made before its release

    Entertainment
  • a day ago

    Lizzo made sad admission about weight loss before revealing she’s used Ozempic to help with dramatic transformation

    Lizzo has wowed fans with her incredible weight loss transformation over the years

    Entertainment
  • a day ago

    Hailey Bieber and Selena Gomez have unfollowed each other on social media and everyone's saying the same thing

    Fans of the big-name stars took to social media to have their say

    Entertainment
  • Christina Applegate missed significant MS symptom years before she got diagnosed with disease
  • Christina Applegate revealed five ‘weird’ symptoms she ignored before realising she had MS
  • Five common early signs of MS as Christina Applegate admitted to ignoring initial symptoms
  • Little-known signs of MS that only affect women as Christina Applegate reveals symptom she noticed whilst filming show