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The sad news was finally confirmed on Friday, although speculation that the couple were splitting have been circulating for weeks.
Just last month, rumours emerged that Kim, 40, had hired top Hollywood lawyer Laura Wasser - who has previously represented Angelina Jolie, Heidi Klum and Kim during her first marriage to Kris Humphries.
According to TMZ, the couple's split is "amicable" and Kim is asking for joint legal and physical custody of their four children.
According to the publication, both Kim and Kanye, 43, are committed to co-parenting together.
Over the last few months, reports suggested Kim and Kanye's marriage was in trouble. Not long after the rapper decided to run for president in the US presidential campaign, he posted a series of shocking tweets about his wife, which he has since apologised for.
In now-deleted tweets, Kanye told his 30 million+ followers that Kim, tried to "lock [him] up with a doctor".
"Kim tried to bring a doctor to lock me up with a doctor," he tweeted on Monday 20th July. "If I get locked up like Mandela... Ya'll will know why."
He added: "Kim was trying to fly to Wyoming with a doctor to lock me up like on the movie Get Out because I cried about saving my daughters life yesterday."
In other tweets, Kanye spoke about trying to "get divorced" from Kim, saying: "I been trying to get divorced since Kim met with Meek [Mill] at the Warldolf for 'prison reform'. I got 200 more to go."
Referring to a 2018 lunch meeting Kim had with American rapper Meek Mill, he added: "Meek is my man and was respectful. That's my dog. Kim was out of line. I'm worth five billion dollars and more than that though Christ. But y'all ain't listen to MJ and now y'all believe them."
Kanye later apologised and Kim posted a statement on Instagram pleading for empathy for her husband's bipolar disorder.
The pair married back in 2014 after first going public with their relationship in 2012. They share four children together: North, seven, Saint, five, Chicago, two and Psalm, one.
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