Kelly Osbourne has explicit response to Ozempic comments following drastic weight loss

Kelly Osbourne has issued a defiant response to those commenting on her body after some fans voiced their concerns.

The 41-year-old previously lifted the lid on having lost 85lb following the birth of her son, Sid, denying she'd relied on popular weight loss drugs, like Mounjaro - things her mother Sharon admitted to using last year.

"I know everybody thinks I took Ozempic," the star claimed back in April. "I did not take Ozempic. I don't know where that came from.

"My mum took Ozempic."

Kelly - whose rock star father Ozzy Osbourne sadly died back in July - sparked conversations earlier this week when she rocked up to the launch of Juliet Sear's new signature bakeware collection at Fortnum & Mason, with a considerably slimmer frame.

Having picked up on criticism over her appearance, the mother-of-one addressed speculation over her figure head on earlier this week, claiming questions on weight loss drugs need to be suppressed.

Kelly shared a photo from a Fortnum & Mason event this week (Instagram/@kellyosbourne)

In a passionate Instagram rant that has since been deleted, she began: "To the people who keep thinking they're being funny and mean by writing comments like 'Are you ill,' or 'Get off Ozempic, you don't look right'. My dad just died, and I'm doing the best that I can, and the only thing I have to live for right now is my family."

The star continued: "And I choose to share my content with you and share the happy side of my life not the miserable side of my life.

"So to all those people, 'f**k off'."

Piers Morgan brought the clip up on his talk show earlier this week while chatting to Kelly's mother, Sharon.

Defending her daughter, the 73-year-old former X-Factor host pointed out the impact that Ozzy's death has had on her family: "She's right. She's lost her daddy, she can't eat right now."

Kelly's appearance sparked conversation among trolls (Instagram/@julietsear)

Kelly's now-deleted rant is far from the first time that she's addressed criticism over her changing physique, having been open on the topic since rising to fame on The Osbournes aged 15.

Speaking to PEOPLE in May, she reflected on the reputation she's inadvertently forged for herself, which has seen her targeted by trolls.

"I have been a drug addict, an alcoholic..." she began. "I’ve been a complete mess, disrespectful to people, horrible - but I got more s**t for being fat than I did for anything else. It’s insane.

Kelly spoke out this week (John Shearer/WireImage)

"You’ll never read an article about me that hasn’t got a comment about my weight."

Adding that the harassment is as bad now as it was when she was at a larger size, Kelly continued: "People [would] say, ‘You’re so pretty. Why don’t you just lose a little bit of weight, and then you’ll be the total package'.

"I tried probably everything that there is out there, whether it be surgery, medication, diet and exercise. I got my mind where I needed it to be, and everything started to fall into place."