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Gastroenterologist reveals one thing they’d ‘never do’ with ibuprofen

Home> Life

Published 13:18 2 Oct 2025 GMT+1

Gastroenterologist reveals one thing they’d ‘never do’ with ibuprofen

Harvard-trained Dr Saurabh Sethi has taken to TikTok to issue a warning over taking the popular painkiller medication

Rhiannon Ingle

Rhiannon Ingle

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Featured Image Credit: Getty Stock Images

Topics: Advice, Explained, Health, Life, Social Media, TikTok, NHS

Rhiannon Ingle
Rhiannon Ingle

Rhiannon Ingle is a Senior Journalist at Tyla, specialising in TV, film, travel, and culture. A graduate of the University of Manchester with a degree in English Literature, she honed her editorial skills as the Lifestyle Editor of The Mancunian, the UK’s largest student newspaper. With a keen eye for storytelling, Rhiannon brings fresh perspectives to her writing, blending critical insight with an engaging style. Her work captures the intersection of entertainment and real-world experiences.

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For many of us, taking painkiller medication is simply a part of our daily lives.

Whether you're popping a paracetamol for a headache or ibuprofen for period cramps, it seems like most people out there have a stash of boxes of the stuff in their bathroom cabinet, handbags, and pockets.

However, a warning has been issued by a gastroenterologist over the latter drug, as he opened up on the serious long-term side effects of taking ibuprofen.

Taking to TikTok, where he boasts over 530k followers, Dr Saurabh Sethi revealed the 'one thing' he would 'never do' as a gastroenterologist.

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"There is one thing I would never do as a gastroenterologist, and that is take too much ibuprofen," he began.

According to the health expert, as many as 75 per cent of people who take them regularly develop gut inflammation, and one in four people can develop ulcers.

A gastroenterologist has issued a stark warning to anyone who regularly takes ibuprofen (Getty Stock Images)
A gastroenterologist has issued a stark warning to anyone who regularly takes ibuprofen (Getty Stock Images)

"I perform endoscopies regularly and see these ulcers first-hand," said Dr Sethi, a gut and liver doctor who was trained at both Harvard and Stanford. "NSAIDs reduce blood flow to the gut, which can harm its lining."

NSAIDs, which stand for non-steroidal anti-inflammatory drugs, are a class of medications used to reduce pain, lower fever, and relieve inflammation, making them useful for conditions like headaches, arthritis, and sprains. Common examples include ibuprofen, aspirin, and naproxen.

He warned: "I have seen young otherwise healthy people come in with gut damage so severe they ended up in the ER just because they did not know the risks of these medications."

Dr Sethi then outlined three things you can do if you're taking these medicines 'more than a couple times a month'.

"First, talk to your doctor about alternatives. Second, talk to your doctor about using a stomach-protecting medication. And third, take these medicines with food to minimise the risk of damage to the gut lining," he concluded.

Your kidneys are the most likely organ to be damaged by excessive ibuprofen, as per the Cleveland Clinic (Guido Mieth / Getty Images)
Your kidneys are the most likely organ to be damaged by excessive ibuprofen, as per the Cleveland Clinic (Guido Mieth / Getty Images)

Outlining the long-term side effects of the medication, the NHS explains: "Ibuprofen can cause ulcers in your stomach or gut, especially if you take it by mouth for a long time or in big doses.

"If you need to take it for a long time, your doctor may also prescribe a medicine to help protect your stomach."

According to the Cleveland Clinic, your kidneys are the most likely organ to be damaged by excessive ibuprofen.

Other potential issues, apart from stomach ulcers, include:

  • Gastrointestinal problems, including bleeding
  • Heart attack
  • Heart failure
  • High blood pressure
  • Liver toxicity
  • Low sodium levels
  • Stroke
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