Matthew Perry’s death has been ruled an accident from the 'acute effects of ketamine', the County of Los Angeles Department of Medical Examiner confirmed.
The 54-year-old was found dead at his home in Los Angeles on Saturday 28 October.
"We are heartbroken by the tragic loss of our beloved son and brother,” his family said in a statement.
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"Matthew brought so much joy to the world, both as an actor and a friend."
The County of Los Angeles Department of Medical Examiner has now confirmed the cause of Perry's death, following the results of an autopsy.
A post-mortem examination concluded that the Friends actor died from the 'acute effects of ketamine', also listing contributing factors that included 'drowning, coronary artery disease and the effects of buprenorphine' – a drug used to treat opioid use disorder.
The County of Los Angeles Department of Medical Examiner said in a statement issued today: "The County of Los Angeles Department of Medical Examiner (DME) determined the cause of death for 54-year-old actor Matthew Langford Perry as the acute effects of ketamine.
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"Contributing factors in Mr. Perry’s death include drowning, coronary artery disease and the effects of buprenorphine (used to treat opioid use disorder). The manner of death is accident.
"On October 28, at approximately 1600 hours, Mr. Perry was found unresponsive in the pool at his residence. After 911 was called, paramedics responded to the scene and death was pronounced.
"DME responded, conducted a scene investigation and then transported Mr. Perry’s body to the DME’s Forensic Science Center for examination.
"On October 29, the deputy medical examiner completed an autopsy on Mr. Perry. Following the completion and receipt of relevant test results, the cause and manner of death were certified."
In the wake of Perry's death, Warner Bros. Television Group - the producers behind Friends - released a statement paying tribute to Perry.
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It said: "We are devastated by the passing of our dear friend Matthew Perry.
"Matthew was an incredibly gifted actor and an indelible part of the Warner Bros Television Group family. The impact of his comedic genius was felt around the world, and his legacy will live on in the hearts of so many.
"This is a heartbreaking day, and we send our love to his family, his loved ones, and all of his devoted fans."
The official Friends Twitter page also tweeted: "We are devastated to learn of Matthew Perry’s passing. He was a true gift to us all. Our heart goes out to his family, loved ones, and all of his fans."
Featured Image Credit: David M. Benett/Dave Benett/Getty Images/NewsmakersTopics: Matthew Perry, Friends, Celebrity