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The Duke of Sussex and Oprah teased upcoming footage from the Apple TV+ show on Monday, in which Meghan Markle also makes an appearance.
The trailer comes ahead of the series' premiere on May 21st.
You can watch it here:
"What words have you heard around mental health?" Harry asks Oprah in the trailer. "Crazy?"
"Lost it, can't keep it together," Oprah suggests.
She then tells the Prince: "All over the world people are in some kind of mental, psychological, emotional pain.
"Being able to say, 'This is what happened what happened to me,' is crucial."
Before we hear Harry - who famously lost his own mother, Princess Diana, in 1997, and has also been outspoken about struggling with media scrutiny in the UK - announce: "To make that decision to receive help is not a sign of weakness.
"In today's world, more than ever, it is a sign of strength."
The camera then pans to the famous imagery of Prince Harry, 12, walking behind his mother's coffin, as a voiceover states: "Treating people with dignity is the first act".
In the trailer, the Duchess of Sussex also makes a cameo in a "Raising the Future" T-shirt, as she pops up over Harry's shoulder as he attends meetings on his laptop.
"The results of this year will be felt for decades," we hear Harry declare, as a snap of Meghan reading to their son, Archie, pops up on the screen. "By kids, families, husbands, wives - everybody."
Oprah and Prince Harry not only co-created the new TV project, but also acted as executive producers.
The series features mental health experts, and famous guests, including Lady Gaga, and aims to highlight individuals from around the world "living with the challenges of mental health issues and addressing their emotional well-being".
This is sure to be a really powerful watch.
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