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The American rock singer, songwriter said that the Westworld actress' claims against him were "horrible distortions of reality".
It comes after the 52-year-old was dropped by his record label and removed from upcoming TV appearances after being publicly named on Instagram as Wood's abuser.
In a powerful statement written on Instagram, the 33-year-old wrote that she was "brainwashed and manipulated into submission" as a teenager, after Manson allegedly started grooming her.
Refuting these claims, and stating that his relationships had always been "entirely consensual", Manson said: "Obviously, my art and my life have long been magnets for controversy, but these recent claims about me are horrible distortions of reality.
"My intimate relationships have always been entirely consensual with like-minded partners. Regardless of how - and why - others are now choosing to misrepresent the past, that is the truth."
It comes after Wood - who was previously engaged to Manson for a short time, in 2010 - said in a powerful statement yesterday: "The name of my abuser is Brian Warner, also known to the world as Marilyn Manson.
"He started grooming me when I was a teenager and horrifically abused me for years. I was brainwashed and manipulated into submission.
"I am done living in fear of retaliation, slander or blackmail. I am here to expose this dangerous man and call out the many industries that have enabled him, before he ruins any more lives.
"I stand with the many victims who will no longer be silent."
Tyla has contacted reps for both Wood and Manson for comment.
Following Wood's allegations and those of other women who came forward, Loma Vista Recordings announced it would not be working with Manson any longer.
It said in a statement the company said: "In light of today's disturbing allegations by Evan Rachel Wood and other women naming Marilyn Manson as their abuser, Loma Vista will cease to further promote his current album, effective immediately.
"Due to these concerning developments, we have also decided not to work with Marilyn Manson on any future projects."
Meanwhile, Deadline report that AMC has pulled an upcoming episode of horror anthology programme, Creepshow, in which the rock singer was supposed to appear.
Starz network has also cut Manson's guest appearance from its series, American Gods.
"Due to the allegations made against Marilyn Manson, we have decided to remove his performance from the remaining episode he is in, scheduled to air later this season. Starz stands unequivocally with all victims and survivors of abuse," the network said.
Westworld star Wood first started dating shock-rocker Manson, 52, in 2007 when she was just 20 years old.
She was thought to be the inspiration for Manson's song 'Heart-Shaped Glasses', the lead single on his 2007 album Eat Me, Drink Me. Wood also stars in the music video.
The actress has previously spoken out about being a victim of sexual and domestic abuse at the hands of an ex-partner - though not naming Manson.
In 2018, she testified before a House Judiciary Subcommittee as part of an effort to get the Sexual Assault Survivors Bill of Rights passed in all 50 American states.
"My experience with domestic violence was this: Toxic mental, physical and sexual abuse which started slow but escalated over time, including threats against my life, severe gaslighting and brainwashing, waking up to the man that claimed to love me raping what he believed to be my unconscious body," she told the subcommittee, though she did not name the person at the time.
Following Evan's statement on Instagram, at least four other women posted their own allegations against Manson, detailing their own catalogue of abuse which they claimed to be victims of sexual assault and coercion.
Manson has previously denied similar accusations of abuse.
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