Speaking about the challenges of the past year, the Good Morning Britain host, 53, said she constantly finds herself asking 'what would Derek do?'.
Speaking about raising her two children, Darcey, 14 and William, 11, while Derek is in hospital, Kate told Good Housekeeping: "I'm not sure I am coping! I honestly don't know how single mums do it; it's just so hard. A lot of the time I find myself thinking, 'What would Derek say?' and 'What would Derek do?'
"I'm lucky that I'm being supported by lots of friends, too, and Ranvir [Singh] has been really helpful because she's been operating as a single mum since her son, Tushaan, was very little.
"I asked her, 'How do you do it?' and she said, 'You just have to accept that you can't do everything.'"
Kate has been warned by doctors that Derek, 53, may never come out of his coma.
Speaking about the situation, Piers Morgan told GMB viewers: "We know from our colleague Kate Garraway, whose husband Derek is still in a coma from COVID. He may never come out of that coma. She's been told this, and it's heartbreaking.
"It has hit right here on our show... It's hit a lot of people now. 100,000 people or more have now lost their lives - think about how many family members they all have. Multiply that and you're getting into millions of people directly affected by COVID-19."
Derek was taken to hospital last spring after he developed coronavirus, and has remained in a severe condition ever since.
Speaking about his current state, Kate added: "It's very much two steps forward, three steps back, but if I think back to where we were in March 2020... When Derek's lungs were solid with infection and his infection rates were the highest doctors had seen in anyone who has lived, we're undoubtedly in a more positive place."
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