| Last updated
There was the iconic anti-bite mask, serial killer Buffalo Bill in drag ("it rubs the lotion on its skin or else it gets the hose again!") and Anthony Hopkins as Dr Hannibal Lecter murmuring softly, "Hello, Clarice".
The 1991 movie, based on the Thomas Harris novel of the same name, dominated at the Academy Awards, scooping Best Picture and Best Actress for Jodie Foster.
Now a brand-new TV series is in the works, following FBI Cadet Clarice Starling a year after she first encounters Hannibal the Cannibal.
Deadline reports that a pilot episode of the series, titled Clarice, has been given the go ahead by CBS.
The series explores the personal story of Clarice Starling, tracking her as she returns to the FBI, taking on new cases involving murderers and sexual predators.
According to Deadline, the series will also see Clarice "navigating the high stakes political world of Washington D.C."
Hannibal Lecter will not be a part of the series. Way too busy eating liver with fava beans, presumably.
Silence of the Lambs spawned five movie spin-offs, including 1986's Manhunter and 2001's Hannibal, but none rivalled the acclaim of the original.
There was NBC's Hannibal TV series too, which won a devoted fan base during its run from 2013 to 2015.
Alex Kurtzman and Jenny Lumet, who will write and executive produce the new Clarice series, said in a joint statement: "After more than 20 years of silence, we're privileged to give voice to one of America's most enduring heroes - Clarice Starling."
"Clarice's bravery and complexity have always lit the way, even as her personal story remained in the dark. But hers is the very story we need today: her struggle, her resilience, her victory. Her time is now, and always."
Chosen for YouChosen for You
Most Read StoriesMost Read