Gaga couldn't hold back tears when she accepted the prestigious award, but she managed to deliver a powerful message about mental health.
She told the crowd: "I'm so proud to be a part of a movie that addresses mental health issues. They're so important.
"And a lot of artists deal with that. And we gotta take care of each other.
"So if you see somebody that's hurting, don't look away.
"And if you're hurting, even though it might be hard, try to find that bravery within yourself to dive deep and go tell somebody and take them up in your head with you."
Watch Lady Gaga perform her Oscar-nominated and Grammy-winning song 'Shallow' at the 61st #GRAMMYs: pic.twitter.com/kOG36CelDG
- Lady Gaga Facts (@LGMonsterFacts) February 11, 2019
A Star Is Born shows Cooper's character Jackson's mind slipping into depression as well as exploring the impact his suicide would have on his family and friends. It's no doubt Gaga's powerful message stems from this and will strike a chord with people all over the world.
Not only did Gaga bag her joint Grammy with Cooper, but she also got one for her album for Joanne for Best Solo Pop Performance.
:sob::heart:a Grammy for Joanne is more than me & my family could ever dream of. I sang that version in one take, & poured my entire life & soul into it. Thank you so much for this gift I am completely shocked. 2nd Grammy win of the night I am so overwhelmed by this kindness. #grammys:musical_score:
- Lady Gaga (@ladygaga) February 10, 2019
She wrote on Twitter: "I'm not gonna be able to wear any makeup tonight. We just won our first of Grammy nominations for the night.
"I'm in tears with honor and gratitude. Thank you @RecordingAcad #Grammys #Grammy and my co-writers and Bradley I love you so much thank you."